Specifications

Fritted Column · Specifications

Standard sizes are listed below. All products comply with GB/T, ASTM, and ISO standard taper systems. Full range 10/19 ~ 60/45 available. Custom IDs, effective lengths, frit grades, and stopcock configurations are available.

Request custom specs

1. Frit Grade Guide (Customizable)

Frit Grade	Pore Size (μm)	Typical Application	Availability
G1	100 ~ 200	Coarse packing support (large particle silica)	✅ Optional
G2	20 ~ 35	General chromatography, most packings	✅ Standard
G3	10 ~ 20	Fine packing support (small particle silica, gel)	✅ Optional
G4	5 ~ 15	Ultra-fine packing, high-resolution separation	✅ Optional
Custom	As required	Custom pore sizes for precise packing matching	✅ Available

2. Standard Fritted Column Sizes

Note: Length notation varies by brand. Professional brands specify "effective length" (from frit top to tube mouth). Some brands specify "total length" (including joint and outlet).

ID (mm)	OD (mm) approx.	Effective Length (mm)	Common Joint	Wall Thickness (mm)	Frit Grade	Separation Scale
10 ~ 13.4	13 ~ 17	200 / 305 / 457	14# / 19# / 24#	1.8 ~ 2.0	G2 (Custom)	Micro (< 50mg)
16 ~ 20	20 ~ 26	203 / 305 / 457	19# / 24#	2.0 ~ 3.0	G2 (Custom)	Small (50-500mg)
26 ~ 32	32 ~ 40	203 / 254 / 305 / 457	24# / 29# / 35/20	2.5 ~ 3.0	G2 (Custom)	Medium (500mg-5g)
40 ~ 46	46 ~ 53	203 / 305 / 457	19# / 22# / 24#	3.0	G2 (Custom)	Preparative
53 ~ 60	60 ~ 67	203 / 254 / 305 / 457	24# / 29#	3.5	G2 (Custom)	Large-scale
73 ~ 80	80 ~ 87	203 / 305 / 457 / 610	24# / 29#	3.5	G2 (Custom)	Batch (> 5g)
90 ~ 100	100 ~ 110	300 / 400 / 500 / 600	24# / 29# / 34#	4.0+	G2 / G3 (Custom)	Industrial
100+	110+	300 / 500 / 700 / 1000 / 1500	24# / 29# / 34# / 40#	4.0+	G2 (Custom)	Mass Production

3. Standard Joint Specifications (GB/ASTM/ISO)

GB/T	ASTM	ISO
14#	14/20	14/23
19#	19/22	19/26
24#	24/40	24/29
29#	29/42	29/32
34#	34/45	34/35
40#	40/50	40/38

4. Additional Configuration Options

Option	Choices	Description
Stopcock	None / Glass / PTFE	PTFE stopcock resists strong acids/bases, no lubrication
Stopcock Bore	2mm / 4mm / 5mm / 8mm	Select based on flow rate requirements
Joint Type	Standard / Inner / Ball & Socket	Ball & socket (e.g., 35/20) for specific adapters
Additional Features	Vacuum barb / Reservoir bulb / Perforated cap	Vacuum chromatography, extended elution, etc.

* Joint numbers (14#, 19#) indicate the largest diameter (mm) of the taper. All are 1:10 taper.
* GB/ASTM/ISO designations are different standard identifiers — physical dimensions are identical and fully interchangeable.
* ★ Frit customization: G1/G2/G3/G4 and custom pore sizes available.
* IDs from 10mm to 200mm+ and effective lengths from 200mm to 1500mm+ available upon request.
* Contact our sales team for MOQ and lead time on custom orders.

✦ Customization Services — We offer custom IDs, effective lengths, joint sizes, frit grades, and stopcock configurations. Share your specific requirements and our technical team will provide a tailored solution.

Product Description

The fritted chromatography column is an enhanced version of the standard chromatography column, featuring a sintered glass frit at the lower end. The frit eliminates the need for manual placement of glass wool or column supports, effectively prevents packing material from washing out, extends packing life, and ensures consistent and reproducible separation performance.

Manufactured from high-borosilicate glass 3.3, the column offers excellent clarity for real-time observation of bed status and sample migration. The upper end features a standard taper joint for connection to solvent reservoirs or chromatography accessories. The G2 frit (20-35μm) is the standard configuration, with G1/G3/G4 and custom pore sizes available to precisely match packing particle size and separation requirements.

✦ Frit Customization Service: G1, G2, G3, G4, and custom pore sizes available. Contact us with your packing particle size and separation requirements for precise frit matching.

Key Features

Borosilicate Glass 3.3: Meets ISO 3585, low thermal expansion, thermal shock resistance up to 280°C, excellent chemical durability
Multi‑Standard Compliance: Precision‑ground 1:10 taper meets GB/T, ASTM E, and ISO 3585 standard taper specifications for full interchangeability
Built-in Sintered Frit: G2 frit (20-35μm) standard; G1/G3/G4 and custom pore sizes available to precisely match packing particle size
Thick-Wall Design: Enhanced strength and safety for pressurized operation
Minimal Dead Volume: Frit design minimizes dead volume to prevent secondary mixing of separated compounds
High Clarity: >92% light transmission for real-time bed observation

Quality Assurance

Each fritted chromatography column is inspected for dimensional accuracy, frit integrity, and taper precision to ensure reliable sealing with all standard joint components. Custom bulk orders are welcome.

Tip: No additional glass wool support is needed — the frit provides reliable packing support. Check the frit for blockage before use. For clogged frits, use ultrasonic cleaning or back-flushing.

Applications

Typical Uses

Column Chromatography

Purification of natural products, synthetic compounds — frit prevents silica gel packing loss

Protein Purification

Affinity, ion exchange, and gel filtration chromatography

Flash Chromatography

Rapid purification (thick-wall design enhances pressurized operation safety)

Vacuum Chromatography

Vacuum barb models enable vacuum-assisted flash chromatography

Preparative Purification

Large-scale sample purification

Industrial Production

Bulk purification, continuous production (extra-long columns)

Compatible Equipment

Standard joint solvent reservoirs, constant-pressure funnels

Chromatography accessories (stopcocks, adapters)

Ring stands and clamps (specialized supports for extra-long columns)

Peristaltic pumps, fraction collectors, vacuum pumps (vacuum models)

Tip: Always use matching standard joint sizes for optimal sealing. Fritted columns can be flexibly combined with other standard joint glassware. The frit is a fragile component — avoid scratching the frit surface with hard objects.

Operation & Maintenance

User Guide

Before Use

Inspect for cracks, chips, or scratches on any joint
Check that the frit is intact and not blocked
Clean all joint surfaces with a soft cloth to remove particulates
Confirm that the joint size matches your accessories
Prepare packing material, eluent, and collection vessels

Packing Procedure (Frit replaces glass wool support)

Mount the column vertically on a stand or specialized support
Add a small volume of eluent to wet the frit
Slowly add packing material while gently tapping the column for even settling
Add a layer of glass wool or filter paper on top of the packing
No glass wool needed at the bottom — the frit provides reliable support

Chromatography Operation

Connect the upper joint to a solvent reservoir or constant-pressure funnel
Apply the sample and begin elution
Collect fractions based on the separation profile
Adjust flow rate to optimize separation

Cleaning & Storage

Rinse immediately after use with appropriate solvent
For clogged frits, use ultrasonic cleaning or back-flushing
Use soft brushes and appropriate detergents for the tube interior
Air dry and store with protective paper between ground joints
Protect the frit and joints from impacts

Fritted Column · Selection Guide

Four key dimensions determine the right fritted column for your application: frit grade, inner diameter, stopcock configuration, and additional features.

1. By Frit Grade (Customizable)

Frit Grade	Pore Size (μm)	Typical Application	Availability
G1	100 ~ 200	Coarse packing (large particle silica, macroporous resin)	✅ Optional
G2	20 ~ 35	General chromatography, most packings	✅ Standard
G3	10 ~ 20	Fine packing (small particle silica, gel filtration)	✅ Optional
G4	5 ~ 15	Ultra-fine packing, high-resolution separation	✅ Optional
Custom	As required	Custom pore sizes for precise packing matching	✅ Available

2. By Inner Diameter

ID	Scale	Typical Application
10 ~ 16mm	Micro (< 50mg)	Analytical separation, purity checks
20 ~ 32mm	Small (50-500mg)	Routine analysis, small-scale prep
40 ~ 60mm	Medium (500mg-5g)	Preparative separation, routine purification
73 ~ 100mm	Large (5-50g)	Large-scale prep, industrial purification
100mm+	Bulk (> 50g)	Industrial production, bulk purification

3. By Stopcock Configuration

Stopcock Type	Features	Typical Use
None	Lower cost, atmospheric chromatography	Standard atmospheric separations
Glass Stopcock	Standard organic solvent compatibility	Most organic chromatography
PTFE Stopcock	Resists acids/bases, no lubrication	Corrosive systems, high purity requirements

4. Quick Selection Checklist

Follow this decision flow to quickly identify the right configuration:

① Packing particle size? Coarse (> 100μm) → G1 | Standard (20-100μm) → G2 | Fine (< 20μm) → G3/G4 | Special → Custom
② Separation scale? Micro → 10-16mm | Small → 20-32mm | Medium → 40-60mm | Large → 73mm+
③ Flow control needed? No → No stopcock | Yes → Glass/PTFE stopcock
④ Vacuum assistance needed? No → Standard | Yes → Vacuum version (with vacuum barb)

✦ Need help selecting? Contact our technical support team with your packing particle size and separation requirements — we'll recommend the optimal configuration, including precise frit grade matching.

Care & Notes

Show care & notes

Safety Precautions

Always operate in a fume hood when handling organic solvents
Wear protective gloves and safety goggles

Do not

Never use cracked or damaged columns
Monitor pressure limits when using pressurized systems — avoid damaging the frit
The frit is sintered glass — avoid scratching with hard objects