Specifications

Component List

All components listed below are included in this kit. Items marked Optional can be customized.

Available Joint Sizes · GB/ISO/ASTM Standards

All sizes share 1:10 standard taper — GB, ISO, and ASTM sizes are interchangeable

14/19 19/26 24/29 (GB·recommended) 29/32 34/35 · 45/40 · 50/42 custom

GB (Chinese) 14/19 · 19/26 · 24/29 · 29/32 ISO 14/19 · 19/26 · 24/29 · 29/32 ASTM (American) 14/20 · 19/22 · 24/40 · 29/42

* All components have matching joint sizes for full system compatibility. ASTM and GB/ISO sizes share 1:10 taper — seal lengths differ but are interchangeable.

Component	Standard Spec	Available Joint Sizes	Upgrade Options	Qty	Link
Please contact us to confirm the available specifications.

📌 Customization Notes:
• Joint size can be selected to match your existing lab system:
GB (Chinese): 14/19 · 19/26 · 24/29 · 29/32
ISO: 14/19 · 19/26 · 24/29 · 29/32
ASTM (American): 14/20 · 19/22 · 24/40 · 29/42
• Reaction vial capacity: 2ml, 5ml (standard), 10ml
• Condenser type: Jacketed (standard) or Air
• Mix and match — no minimum order quantity

💡 Recommended Add-Ons: Micro heating block (for 2ml/5ml vials) · Magnetic stirrer · Micro thermometer (0~150℃) · Pipettor · Stir bars

Product Description

I. What Is the Microscale Synthesis Kit

The microscale synthesis kit is a complete toolset for microscale organic synthesis. It includes the most commonly used components — reaction vials, condensers, connectors, and flasks — all with 14/10 standard joints for complete interchangeability. Open the case and you can assemble apparatus for reflux, distillation, inert gas protection, and more.

Unlike standard-scale synthesis, microscale synthesis uses milligrams and microliters — less reagent, shorter reaction times, and less waste. This kit is optimized for microscale work with appropriately sized glassware and connections to minimize holdup volume.

✦ Advantages of Microscale Synthesis:

① Reagent savings — milligram-scale reactions make expensive reagents affordable
② Faster reactions — efficient heat and mass transfer in small volumes
③ Safer — smaller exotherms, less hazardous waste
④ Greener — reduced waste generation
⑤ Ideal for screening — saves significant time and resources

II. Kit Contents

This kit includes the following core components:

Micro Reaction Vials (2ml × 3, 5ml × 3) — Main reaction vessels, with 14/10 joints
Micro Jacketed Condenser × 1 — Water-cooled reflux
Micro Air Reflux Condenser × 1 — Simple reflux, no water needed
Micro Connectors × 5 — Various angles for connecting vials and condensers
Micro Flasks (10ml × 2) — For distillation or receiving
Foam-Lined Storage Case × 1 — Dedicated slots for every component

III. Jacketed vs Air Condenser

Jacketed Condenser (water-cooled) — For reflux and distillation; higher cooling efficiency; suitable for medium-boiling solvents (60–150℃)
Air Condenser (no water) — For high-boiling solvents (>150℃); air cooling prevents thermal stress cracking from water-cooling temperature differences

IV. Material & Workmanship

All glass components are manufactured from borosilicate glass 3.3 — chemically resistant and thermally shock-resistant. 14/10 standard joints are precision-machined for reliable sealing. Vials have uniform wall thickness for even heating. The foam-lined storage case provides dedicated slots for every component — easy access, secure storage, and protection from damage.

Applications

Typical Applications

Microscale Organic Synthesis

Milligram-scale reaction condition screening and route exploration

Natural Product Chemistry

Derivatization and structural modification of micro-quantity natural products

Medicinal Chemistry

Micro-synthesis and optimization of drug candidates

Methodology Research

Microscale validation of new reactions and catalysts

Teaching Labs

University microscale organic chemistry laboratory instruction

Expensive Reagent Reactions

Reactions with precious metal catalysts or isotope-labeled compounds

Suitable Conditions

Reaction scale: 0.1–5ml
Reagent quantity: milligram-scale (1–100mg)
Suitable for atmospheric pressure reactions (pressurized reactions require special design)
Reaction temperature: room temperature to 250℃ (with heating block)

Reaction Type	Recommended Components	Notes
Please contact us to confirm the available specifications.

Operation & Maintenance

User Guide

The key to the microscale synthesis kit is flexible assembly — choose the right components for your reaction type. Here are common assembly examples.

🚨 Three rules to remember:
① Align all joints properly — misalignment causes leaks or joint damage
② Heat slowly — bumping in micro samples means total loss
③ Clean immediately after use — residues in micro glassware are extremely difficult to remove once dry

I. Before You Start

Check all glass components for cracks — cracked glass is unsafe
Check that joints are clean — residues affect sealing
Confirm all components are in the storage case — each slot corresponds to one piece
Prepare heating block and magnetic stirrer (if needed)

Micro Reflux Setup

Add sample and stir bar to reaction vial (2ml or 5ml)
Connect the jacketed condenser via a connector
Keep the condenser top open
Heat with the heating block with magnetic stirring

High-Boiling Reflux (Air Condenser)

Add sample to reaction vial
Connect the air reflux condenser via a connector
Keep the condenser top open
Heat with the heating block — no cooling water needed

Inert Gas Protection Reaction

Add sample to reaction vial
Connect the jacketed condenser via a connector
Introduce nitrogen or argon through the condenser top
Maintain positive pressure

III. Reaction Control

Heat slowly with the heating block — micro samples bump easily and total loss is the consequence
Once reflux is stable, watch the condensation ring in the condenser — its position reflects reflux intensity
Reaction time is typically 1–6 hours (faster than standard-scale reactions)
Sample periodically — use a pipette to withdraw a few microliters for analysis

IV. Shutdown & Cleaning

Turn off the heat first — allow the apparatus to cool naturally
Disassemble once cooled to room temperature
Clean immediately — residues in micro glassware are extremely difficult to remove once dry
Dry components and return to their designated slots in the storage case
Check that all components are present — each slot corresponds to one component

📌 Component Selection Tips:

① Solvent boiling point below 150℃ — use jacketed condenser with cooling water
② Solvent boiling point above 150℃ — use air condenser (prevents cracking from thermal shock)
③ Need inert gas protection — jacketed condenser (easier to introduce gas from the top)
④ Connector angle: Straight connector for simple reflux; angled connectors for distillation or separatory setups

💡 From a Seasoned Lab Hand:

"The essence of microscale synthesis is 'less is more' — less reagent, less solvent, less time, but not less yield."
Stir bar selection: 2ml vials use micro stir bars (5×2mm); 5ml vials use standard micro stir bars (10×3mm) — too large and they won't spin; too small and they won't mix.
Heating block temperature: Set the block 20–30℃ above the solvent boiling point. Don't place the flask directly on the block — use a layer of aluminum foil or glass wool for even heating.
Workup: Microscale workup is also microscale — use micro pipettes for transfers, micro centrifuge tubes for collection, and a micro rotary evaporator for concentration.

Care & Notes

Show care & notes

⚠️ Safety & Compliance Checklist

Work in a fume hood

— even small amounts of organic vapor are hazardous

NO open flame when heating flammable solvents

— use a heating block

Don't force joints

— micro glassware has thinner walls and is more fragile

The condenser top must remain open

— sealed systems will explode when heated

Do not

Never use cracked glassware

Microscale Synthesis Kit